Polarised Asymmetric Inheritance of Accumulated Protein Damage in Higher Eukaryotes
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چکیده
منابع مشابه
Polarised Asymmetric Inheritance of Accumulated Protein Damage in Higher Eukaryotes
Disease-associated misfolded proteins or proteins damaged due to cellular stress are generally disposed via the cellular protein quality-control system. However, under saturating conditions, misfolded proteins will aggregate. In higher eukaryotes, these aggregates can be transported to accumulate in aggresomes at the microtubule organizing center. The fate of cells that contain aggresomes is cu...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2006
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.0040417